MR imaging – FTD Talk

MRI Imaging

Our research focuses on developing imaging biomarkers for trials. We have worked on understanding the role of cortical and subcortical structures in FTD using different imaging techniques such as voxel-based morphometry and both manual and automatic segmentation of regions of interest. We also investigate the role that loss of structural and functional connectivity has in the FTD spectrum using diffusion tensor imaging, neurite orientation dispersion and density imaging, and resting state functional MRI. Our team work closely with David Cash at the Dementia Research Centre and David Thomas at the Wellcome Trust Centre for Neuroimaging, both of whom have been involved in the GENFI study. Ongoing projects include:

Understanding the role of subcortical structures and their connectivity in FTD
Comparison of analysis techniques of structural imaging for use in clinical trials
Developing optimal longitudinal measures of atrophy and both structural and functional connectivity
Investigating the role of NODDI in FTD

Team Members

Honorary Fellow

Martina Bocchetta

Posters

AAIC 2021 (virtual, July 2021): Pattern of progression in MAPT-related frontotemporal dementia: results from the GENFI study
AAIC 2021 (virtual, July 2021): Detecting clinical progression from abnormal regional brain volumes at baseline in genetic frontotemporal dementia
ARUK 2021 (virtual, March 2021): Pattern of progression in MAPT-related frontotemporal dementia: results from the GENFI study
ARUK 2021 (virtual, March 2021): Differential early subcortical involvement in genetic frontotemporal dementia within the GENFI cohort
11th ICFTD (Sydney, November 2018): Amygdalar subnuclei are particularly affected in tau-MAPT, tau-Pick’s disease and TDP-43 type C-associated frontotemporal dementia
11th ICFTD (Sydney, November 2018): Comparison of automated segmentation tools in FTD: Implications for imaging biomarker choice in clinical trials
11th ICFTD (Sydney, November 2018): Salience and default mode network connectivity changes in frontotemporal dementia subtypes
First International Symposium on PSP & CBD (London, October 2018): A novel automated segmentation tool detects differential brainstem involvement in atypical parkinsonian syndromes
AAIC 2017 (London, July 2017): Thalamic atrophy in frontotemporal dementia: not just a C9orf72 problem
AAIC 2017 (London, July 2017): Pathological correlates of white matter hyperintensities on cadaveric MRI in progranulin-associated frontotemporal dementia
AAIC 2017 (London, July 2017): SQSTM1 mutations in frontotemporal dementia are associated with asymmetrical focal temporal lobe atrophy
10th ICFTD (Munich, September 2016): Clinical, genetic and pathological stratification in FTD: implications for clinical trial design
ARUK Conference 2016 (Manchester, March 2016): Multimodal structural imaging analysis of C9orf72-associated FTD
ARUK Conference 2016 (Manchester, March 2016): Phenomenology and anatomy of abnormal behaviours in FTD as measured by the Cambridge Behavioural Inventory.
AAIC 2015 (Washington, July 2015): Detailed structural analysis of the hypothalamus in behavioural variant frontotemporal dementia
AAIC 2015 (Washington, July 2015): Volumetry of the cerebellum and its subregions in genetic frontotemporal dementia
AAIC 2015 (Washington, July 2015): A cross-sectional and longitudinal investigation of the CBI-R in bvFTD
9th ICFTD (Vancouver, October 2014): Hypothalamic atrophy in behavioural variant frontotemporal dementia and its relationship to eating behaviour
9th ICFTD (Vancouver, October 2014): Longitudinal pattern of cortical thinning in bvFTD

Publications

A data-driven model of brain volume changes in progressive supranuclear palsy. Scotton WJ, Bocchetta M, Todd E, Cash DM, Oxtoby N, VandeVrede L, Heuer H; PROSPECT Consortium, 4RTNI Consortium, Alexander DC, Rowe JB, Morris HR, Boxer A, Rohrer JD, Wijeratne PA. Brain Commun. 2022;4(3):fcac098.
Thalamic and Cerebellar Regional Involvement across the ALS-FTD Spectrum and the Effect of C9orf72. Bocchetta M, Todd EG, Tse NY, Devenney EM, Tu S, Caga J, Hodges JR, Halliday GM, Irish M, Piguet O, Kiernan MC, Rohrer JD, Ahmed RM. Brain Sci. 2022 Mar 1;12(3):336.
A comparison of automated atrophy measures across the frontotemporal dementia spectrum: Implications for trials. Gordon E, Bocchetta M, Nicholas J, Cash DM, Rohrer JD. Neuroimage Clin. 2021 [Epub ahead of Print].
Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia. Bocchetta M, Malpetti M, Todd EG, Rowe JB, Rohrer JD. Brain Commun. 2021 Jul 16;3(3):fcab158.
Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling. Young AL, Bocchetta M, Russell LL, Convery RS, Peakman G, Todd E, Cash DM, Greaves CV, van Swieten J, Jiskoot L, Seelaar H, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Williams SCR, Alexander DC, Rohrer JD; Genetic FTD Initiative (GENFI). Neurology. 2021 Aug 31;97(9):e941-e952.
Differential early subcortical involvement in genetic FTD within the GENFI cohort. Bocchetta M, Todd E, Peakman G, Cash D, Convery R, Russell L, Thomas D, Iglesias JE, van Swieten J, Jiskoot L, Seelaar H, Borroni B, Galimberti D, Sanchez-Valle R, Laforce R, Moreno F, Synofzik M, Graff C, Masellis M, Tartaglia MC, Rowe B, Vandenberghe R, Finger E, Tagliavini F, de Mendonca A, Santana I, Butler C, Ducharme S, Gerhard A, Danek A, Levin J, Otto M, Sorbi S, Le Ber I, Pasquier F, Rohrer JD. Neuroimage Clin. 2021;30:102646.
Analysis of brain atrophy and local gene expression in genetic frontotemporal dementia. Altmann A, Cash DM, Bocchetta M, Heller C, Reynolds R, Moore K, Convery RS, Thomas DL, van Swieten JC, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Frisoni G, Ghidoni R, Sorbi S, Otto M, Ryten M, Rohrer JD; Genetic FTD Initiative, GENFI. Brain Commun. 2020;2(2):fcaa122.
Automated segmentation of the hypothalamus and associated subunits in brain MRI. Billot B, Bocchetta M, Todd E, Dalca AV, Rohrer JD, Iglesias JE. Neuroimage. 2020 (Epub ahead of print).
In vivo staging of frontotemporal lobar degeneration TDP-43 type C pathology. Bocchetta M, Iglesias Espinosa MDM, Lashley T, Warren JD, Rohrer JD. Alzheimers Res Ther. 2020;12(1):34.
Basal forebrain atrophy in frontotemporal dementia. Convery RS, Neason MR, Cash DM, Cardoso MJ, Modat M, Ourselin S, Warren JD, Rohrer JD, Bocchetta M. Neuroimage Clin. 2020;26:102210.
Thalamic Nuclei in Frontotemporal Dementia: Mediodorsal Nucleus Involvement Is Universal but Pulvinar Atrophy Is Unique to C9orf72. Bocchetta M, Iglesias JE, Neason M, Cash DM, Warren JD, Rohrer JD. Hum Brain Mapp. 2020;41(4):1006-1016.
Automated Brainstem Segmentation Detects Differential Involvement in Atypical Parkinsonian Syndromes. Bocchetta M, Iglesias JE, Chelban V, Jabbari E, Lamb R, Russell LL, Greaves CV, Neason M, Cash DM, Thomas DL, Warren JD, Woodside J, Houlden H, Morris HR, Rohrer JD. J Mov Disord. 2020;13(1):39-46.
White Matter Hyperintensities in Progranulin-Associated Frontotemporal Dementia- A Longitudinal GENFI Study. Sudre CH, Bocchetta M, Heller C, Convery R, Neason M, Moore KM, Cash DM, Thomas DL, Woollacott IOC, Foiani M, Heslegrave A, Shafei R, Greaves C, van Swieten J, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Frisoni GB, Sorbi S, Otto M, Zetterberg H, Ourselin S, Cardoso MJ, Rohrer JD; GENFI. Neuroimage Clin. 2019;24:102077.
Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA. Bocchetta M, Iglesias JE, Russell LL, Greaves CV, Marshall CR, Scelsi MA, Cash DM, Ourselin S, Warren JD, Rohrer JD. Alzheimers Res Ther. 2019;11(1):41.
Amygdala subnuclei are differentially affected in the different genetic and pathological forms of frontotemporal dementia. Bocchetta M, Iglesias JE, Cash DM, Warren JD, Rohrer JD. Alzheimers Dement (Amst). 2019;11:136-141.
Optic Nerve Thinning and Neurosensory Retinal Degeneration in the rTg4510 Mouse Model of Frontotemporal Dementia. Harrison IF, Whitaker R, Bertelli PM, O’Callaghan JM, Csincsik L, Bocchetta M, Ma D, Fisher A, Ahmed Z, Murray TK, O’Neill MJ, Rohrer JD, Lythgoe MF, Lengyel I. Acta Neuropathol Commun. 2019;7(1):4.
Presymptomatic white matter integrity loss in familial frontotemporal dementia in the GENFI cohort: A cross- sectional diffusion tensor imaging study. Jiskoot LC, Bocchetta M, Nicholas JM, Cash DM, Thomas D, Modat M, Ourselin S, Rombouts SARB, Dopper EGP, Meeter LH, Panman JL, van Minkelen R, van der Ende EL, Donker Kaat L, Pijnenburg YAL, Borroni B, Galimberti D, Masellis M, Tartaglia MC, Rowe J, Graff C, Tagliavini F, Frisoni GB, Laforce R Jr, Finger E, de Mendonça A, Sorbi S; Genetic Frontotemporal dementia Initiative (GENFI), Papma JM, van Swieten JC, Rohrer JD. Ann Clin Transl Neurol. 2018;5(9):1025-1036.
Pathological correlates of white matter hyperintensities in a case of progranulin mutation associated frontotemporal dementia. Woollacott IOC, Bocchetta M, Sudre CH, Ridha BH, Strand C, Courtney R, Ourselin S, Cardoso MJ, Warren JD, Rossor MN, Revesz T, Fox NC, Holton JL, Lashley T, Rohrer JD. Neurocase. 2018;24(3):166-174.
Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia. Bocchetta M, Iglesias JE, Scelsi MA, Cash DM, Cardoso MJ, Modat M, Altmann A, Ourselin S, Warren JD, Rohrer JD. J Alzheimers Dis. 2018;64(2):497-504.
Thalamic atrophy in frontotemporal dementia – Not just a C9orf72 problem. Bocchetta M, Gordon E, Cardoso MJ, Modat M, Ourselin S, Warren JD, Rohrer JD. Neuroimage Clin. 2018;18:675-681.
Patterns of Gray Matter Atrophy in Genetic Frontotemporal Dementia- Results From the GENFI Study. Cash DM, Bocchetta M, Thomas DL, Dick KM, van Swieten JC, Borroni B, Galimberti D, Masellis M, Tartaglia MC, Rowe JB, Graff C, Tagliavini F, Frisoni GB, Laforce R Jr, Finger E, de Mendonça A, Sorbi S, Rossor MN, Ourselin S, Rohrer JD; Genetic FTD Initiative, GENFI. Neurobiol Aging. 2018;62:191-196.
White matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohort. Sudre CH, Bocchetta M, Cash D, Thomas DL, Woollacott I, Dick KM, van Swieten J, Borroni B, Galimberti D, Masellis M, Tartaglia MC, Rowe JB, Graff C, Tagliavini F, Frisoni G, Laforce R Jr, Finger E, de Mendonça A, Sorbi S, Ourselin S, Cardoso MJ, Rohrer JD; Genetic FTD Initiative, GENFI. Neuroimage Clin. 2017;15:171-180.
The TMEM106B risk allele is associated with lower cortical volumes in a clinically diagnosed frontotemporal dementia cohort. Harding SR, Bocchetta M, Gordon E, Cash DM, Cardoso MJ, Druyeh R, Ourselin S, Warren JD, Mead S, Rohrer JD. J Neurol Neurosurg Psychiatry. 2017;88(11):997-998.
Patterns of regional cerebellar atrophy in genetic frontotemporal dementia. Bocchetta M, Cardoso MJ, Cash DM, Ourselin S, Warren JD, Rohrer JD. Neuroimage Clin. 2016;11:287-290.
The habenula: an under-recognised area of importance in frontotemporal dementia? Bocchetta M, Gordon E, Marshall CR, Slattery CF, Cardoso MJ, Cash DM, Espak M, Modat M, Ourselin S, Frisoni GB, Schott JM, Warren JD, Rohrer JD. J Neurol Neurosurg Psychiatry. 2016;87(8):910-2.
Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia. Bocchetta M, Gordon E, Marshall CR, Slattery CF, Cardoso MJ, Cash DM, Espak M, Modat M, Ourselin S, Frisoni GB, Schott JM, Warren JD, Rohrer JD. J Neurol. 2015;262(12):2635-42.
Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis. Rohrer JD, Nicholas JM, Cash DM, van Swieten J, Dopper E, Jiskoot L, van Minkelen R, Rombouts SA, Cardoso MJ, Clegg S, Espak M, Mead S, Thomas DL, De Vita E, Masellis M, Black SE, Freedman M, Keren R, MacIntosh BJ, Rogaeva E, Tang-Wai D, Tartaglia MC, Laforce R Jr, Tagliavini F, Tiraboschi P, Redaelli V, Prioni S, Grisoli M, Borroni B, Padovani A, Galimberti D, Scarpini E, Arighi A, Fumagalli G, Rowe JB, Coyle-Gilchrist I, Graff C, Fallström M, Jelic V, Ståhlbom AK, Andersson C, Thonberg H, Lilius L, Frisoni GB, Pievani M, Bocchetta M, Benussi L, Ghidoni R, Finger E, Sorbi S, Nacmias B, Lombardi G, Polito C, Warren JD, Ourselin S, Fox NC, Rossor MN, Binetti G. Lancet Neurol. 2015;14(3):253-62.